​​A Natural Solution to a Age-Old Problem

Cannabis has been used to treat headaches for centuries, but only recently has modern science begun to unravel why it might be effective. The plant contains compounds called cannabinoids that interact with our body's own endocannabinoid system - a complex network involved in pain regulation and other crucial functions.
Two key players in this story are THC and CBD, the most well-known cannabinoids in marijuana. THC mimics one of our body's natural pain-fighting molecules, while CBD works through multiple pathways to potentially calm overactive brain signals associated with migraines. And CBG is emerging as a supplement  to keep migraine at bay. 

A Deficiency Theory

Intriguingly, some researchers propose that a deficiency in our natural endocannabinoids might contribute to chronic migraines. This "Clinical Endocannabinoid Deficiency" theory suggests that cannabis could help restore balance to an out-of-whack system.

Hope on the Horizon

While more research is needed, early studies show promise. Cannabis may help reduce both the frequency and duration of migraine attacks for some sufferers. This is particularly encouraging news for those who haven't found relief with conventional treatments or who struggle with medication side effects.

A Word of Caution

It's important to note that cannabis isn't a one-size-fits-all solution. The optimal form and dosage can vary widely between individuals. As with any treatment, it's crucial to consult with a healthcare provider knowledgeable about both migraines and medical cannabis.

The Future is Female (and Green?)

As women continue to be disproportionately affected by migraines, the potential of cannabis as a treatment option is an exciting development. With ongoing research and evolving attitudes towards marijuana, we may be on the cusp of a new era in migraine management - one that draws on both ancient wisdom and cutting-edge science to bring relief to millions.
How Cannabis Can Help Cannabis interacts with the body's endocannabinoid system (ECS), which plays a role in various physiological processes, including pain sensation, mood, and sleep. For fibromyalgia and CFS patients, this interaction can potentially help manage symptoms and improve quality of life.

The main cannabinoids in cannabis affect the body in different ways

• THC binds directly to cannabinoid receptors and can help with pain, mood, and appetite stimulation, reducing nausea and vomiting.

• CBD helps reduce inflammation and the ache and sensitivity experienced during a migraine attack.

 

CBG acts similarly to CBD but is a powerful anti-inflammatory which helps keep pain in check by reducing inflammation.
In most studies, the recommended dosage is 1:1 CBD to THC, but at higher doses >5MG - 10MG. Some patients keep a vape pen in their safe for a quick cessation of symptoms so they can rest and heal. Others find fast-acting Pro-tabs work as a longer-term relief. In all cases, OUI does not recommend driving or operating heavy machinery after consumption.
There is a growing theory that some migraines are caused by Endocannabinoid Deficiency (CED). According to the Clinical Endocannabinoid Deficiency (CED) theory, endogenous cannabinoids, particularly in chronic migraine, may be involved in migraine pathophysiology.

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Chronic Migraine

There is evidence that suggests people with chronic migraines have much lower levels of AEA (anandamide, an endocannabinoid) in their cerebral fluid than people without migraines.

In the population with chronic migraines, AEA reuptake and metabolism enzyme levels have also been found to be significantly decreased.
The theory suggests that a lack of endogenous cannabinoids might contribute to the development of chronic migraines.
 

Stay tuned – OUI is staying on top of the latest research and will update this guide regularly with information you can trust and share with your doctors and friends.